Annotation of a Research Study
Annotation of a Research Study
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Annotation of Quantitative Research Article To Prepare: For this assignment, read the attached research article. Complete an annotation of the article using the attached “Annotation Guideline” as a guide. Paper Guidelines: • Communication plan needs to be at minimum 3 pages with 4 references • Paper is written in Double-Space • Font size 12 & Times New Roman font • Section headers in APA format • Additional Reference page at the end with APA citations Outline Section headers, in APA format for each section below: • Provide the reference list entry for this article in APA Style followed by a three-paragraph annotation that includes: o Summary o Analysis o An Application similar to the example in the attachment. Quantitative Drug-Susceptibility in Patients Treated for Multidrug-Resistant Tuberculosis in Bangladesh: Implications for Regimen Choice 7/3/19, 7(28 PM Quantitative Drug-Susceptibility in Patients Treated for Multidrug-Resistant Tuberculosis in Bangladesh: Implications for Regimen Choice Scott K. Heysell , Shahriar Ahmed , Sara Sabrina Ferdous, Md. Siddiqur Rahman Khan, S. M. Mazidur Rahman, Jean Gratz, Md. Toufiq Rahman, Asif Mujtaba Mahmud, Eric R. Houpt, Sayera Banu Published: February 24, 2015 https://doi.org/10.1371/journal.pone.0116795 Abstract Background Multidrug-resistant tuberculosis (MDR-TB) treatment in Bangladesh is empiric or based on qualitative drug-susceptibility testing (DST) by comparative growth in culture media with and without a single drug concentration. Methods Adult patients were enrolled throughout Bangladesh during the period of 2011–2013 at MDR-TB treatment initiation. Quantitative DST by minimum inhibitory concentration (MIC) testing for 12 first and second-line anti-TB drugs was compared to pretreatment clinical characteristics and treatment outcomes. MIC values at or one dilution lower than the resistance breakpoint used for qualitative DST were categorized as borderline susceptible, and MIC values one or two dilutions greater as borderline resistant. Results Seventy-four patients were enrolled with a mean age of 35 ±15 years, and 51 (69%) were men. Of the rifampin isolates with MIC >1.0 μg/ml, 12 (19%) were fully susceptible or borderline susceptible to rifabutin (MIC ≤0.5 μg/ml). Amikacin was fully susceptible in 73 isolates (99%), but kanamycin in only 54 (75%) (p
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