Types of extraneous variables

Comment1

According to Grove, Gray, & Burns (2015), extraneous variables are present in all studies and can affect the study and the relationships among the variables.  Researchers
must continually look for extraneous variables throughout the research to prevent a biased impact.  They can be confounding, which means they are not recognized until the study is in progress, or environmental, which includes the climate, family, etc. Extraneous variables are more of a concern in quantitative research because they can prevent the researcher from obtaining a clear understanding and they are not recognized until the study is in progress but profoundly affect the outcome of the study (Gray, et al, 2015).  While in most qualitative studies, extraneous variables are usually controlled because subjects are studied in their natural environments.  By selecting a sampling of
participants who are characteristic of the population being studied, extraneous variables can be controlled by the researcher.   Grove, et al (2015) provides the example of research on the effect of relaxation therapy and the patient’s perception of incisional pain.  In order to control extraneous variables, the researcher needed a sampling of patients who are in a hospital environment and receiving one type of intravenous pain medication.   This type of sampling would reduce the extraneous variables such as surgical incision and time, amount and type of pain medication administered postoperatively and their perception of incisional pain (Grove, et al, 2015).

Comment 2

There are 4 types of extraneous variables:

*Situational variables- which are aspects of the environment that might affect the participant’s behavior. For example; noise, temperature, lighting conditions. Situational variables should be controlled so they are the same for all participants.

*Participant/person variables- This refers to the ways in which each participant varies from the other, and how this could affect the results. For example; mood, intelligence, anxiety, nerves, concentration.

*Experimenter/ investigator effects- The experimenter unconsciously conveys to participants how they should behave – this is called experimenter bias.

*Demand characteristics- these are all the clues in an experiment which convey to the participant the purpose of the research. Experimenters should attempt to minimize these factors by keeping the environment as natural as possible, carefully following standardized procedures.

Invisibility in Nursing

Invisibility of Nursing Paper Assignment Details Write a 3-5 page APA formatted paper on your exploration of the “invisibility of nursing” phenomenon, using the article identified here: Rezaei-Adaryani, M., Salsali, M., & Mohammadi, E. (2012). Nursing image: An evolutionary

concept analysis. Contemporary Nurse: A Journal for the Australian Nursing Profession, 43(1), 81-89. doi:10.5172/conu.2012.43.1.81

Discuss nursing documentation as it relates to patient discharge abstracts and the identification of nursing sensitive outcomes. Explore the process for developing standards and the role of the American Nurses Association in promoting standardized terminologies. What are some of the issues surrounding the use of standardized terminologies? What are some of the benefits? Explore the International Health Terminology Standards Development Organization (IHTSDO).Discuss the focus of development and adoption of standard clinical terminology and how this information may be of value to an informatics nurse. Be sure to use at least 5 references to support your work, in addition to the following: Werley, H. H., Devine, E. C., Zorn, C. R., and Westra, B. L. (1991). The nursing minimum data

set: abstraction tool for standardized, comparable, essential data. The American Journal of Public Health, 81(4), 421-426

(Search the CINAHL database for the article on the nursing minimum data set in the Hondros Online Library.) Criteria Possible Score Student Score

1. Provide an introductory paragraph, summarizing the phenomenon identified as the invisibility of nursing

12

2. Discuss the development and promotion of standards, standardized terminologies

12

3. Include benefits, challenges of using standardized terminologies as related to creating a stronger visibility of nursing

18

4. Analyze the potential value of standardization to informatics nurses

18

5. Cite at least five scholarly resources 15

6. Writing skills- grammar, spelling, format, APA citations, maximum 5 pages

15

Possible Score 90http://hondros.libguides.com/Homehttp://hondros.libguides.com/Home

Effects of Disease on the Health Care Industry: Endocrine System Health

Effects of Disease on the Health Care Industry: Endocrine System HealthHCS/245 Version 82

University of Phoenix Material

Effects of Disease on the Health Care Industry: Endocrine System Health

Complete the table on the following page. Choose 2 diseases or disorders to complete the table.Be sure to properly cite references and sources for any information or facts used.

A general example has been provided for you.

Example:

Disease or DisorderTreatment ModalitiesCultural Beliefs/Practices Affecting this DiseaseEpidemiological StatisticsAvailable Consumer Resources(e.g., financing, information, support)Impact on Society
Acquired Immunodeficiency Syndrome (AIDS)· Prevention (education, exposure avoidance)· Antiretroviral treatment (required to begin directly after infection)· Antiviral medications sometimes slow disease progression but cannot cure it once contracted.· AIDS is a disease that only affects the LGBT community (myth).· Contracting HIV is an automatic death sentence (myth).· HIV/AIDS is currently incurable (fact).· Education and proper preventive measures are crucial in fighting this disease.· Worldwide, 2.5 million new cases reported in 2011 (CDC)· 635,000 individuals with AIDS have died in the United States to date (CDC).· An estimated 1.1 million people in U.S. were living with AIDS in 2009 (CDC).· Websites:www.cdc.gov/hiv/default.htmlwww.aidshealth.orgwww.aids.gov· Funding for prevention and research from the government and private sector· Educational programs, UNICEF· Considered a worldwide epidemic (Shi, 2014)· In 2012, the U.S. government spent more than $20 billion on HIV/AIDS programs and research.· Has an impact on social lives and sexual practices of all citizens in a given society in one way or another.

References

Shi, L. (2014). Introduction to Health Policy. Chicago, IL: Health Administration Press. Washington, D.C.: AUPHA Press. Centers for Disease Control and Prevention. (2013). Retrieved from www.cdc.gov/hiv/default.html

Complete the table below for 2 diseases that you have chosen that affects the endocrine system. In each box, you are required to list 3 to 5 bulleted statements regarding the heading of that box.

Cite your sources using APA format.

This section is due in Week Four.

Chosen Endocrine Disease or DisorderTreatment ModalitiesCultural Beliefs/Practices Affecting this DiseaseEpidemiological StatisticsAvailable Consumer Resources(e.g., financing, information, support)Impact on Society
List chosen disease here·····

References

Copyright © 2018 by University of Phoenix. All rights reserved.

Cardiovascular Health

Effects of Disease on the Health Care Industry: Cardiovascular HealthHCS/245 Version 82

University of Phoenix Material

Effects of Disease on the Health Care Industry: Cardiovascular Health

Complete the table on the following page. Choose 2 diseases or disorders to complete the table.Be sure to properly cite references and sources for any information or facts used.

A general example has been provided for you.

Example:

Disease or DisorderTreatment ModalitiesCultural Beliefs/Practices Affecting this DiseaseEpidemiological StatisticsAvailable Consumer Resources(e.g., financing, information, support)Impact on Society
Acquired Immunodeficiency Syndrome (AIDS)· Prevention (education, exposure avoidance)· Antiretroviral treatment (required to begin directly after infection)· Antiviral medications sometimes slow disease progression but cannot cure it once contracted.· AIDS is a disease that only affects the LGBT community (myth).· Contracting HIV is an automatic death sentence (myth).· HIV/AIDS is currently incurable (fact).· Education and proper preventive measures are crucial in fighting this disease.· Worldwide, 2.5 million new cases reported in 2011 (CDC)· 635,000 individuals with AIDS have died in the United States to date (CDC).· An estimated 1.1 million people in U.S. were living with AIDS in 2009 (CDC).· Websites:www.cdc.gov/hiv/default.htmlwww.aidshealth.orgwww.aids.gov· Funding for prevention and research from the government and private sector· Educational programs, UNICEF· Considered a worldwide epidemic (Shi, 2014)· In 2012, the U.S. government spent more than $20 billion on HIV/AIDS programs and research.· Has an impact on social lives and sexual practices of all citizens in a given society in one way or another.

References

Shi, L. (2014). Introduction to Health Policy. Chicago, IL: Health Administration Press. Washington, D.C.: AUPHA Press. Centers for Disease Control and Prevention. (2013). Retrieved from www.cdc.gov/hiv/default.html

Complete the table below for 2 diseases that you have chosen that affect cardiovascular health. In each box, you are required to list 3 to 5 bulleted statements regarding the heading of that box.

Cite your sources using APA format.

This section is due in Week Three.

Chosen Cardiovascular Disease or DisorderTreatment ModalitiesCultural Beliefs/Practices Affecting this DiseaseEpidemiological StatisticsAvailable Consumer Resources(e.g., financing, information, support)Impact on Society
List chosen disease here·····

References

Copyright © 2018 by University of Phoenix. All rights reserved.

fitness plan

Individualized Fitness Plan

Using your fitness assessment analysis, develop a fitness plan with short term goals for this term as well as long range, lifetime fitness goals, using the FITT principle, and with an activity plan for the entire week. Your fitness plan should include activities and exercises you like to do! Your weekly fitness plan should include exercises/activities you plan on engaging in during activity classes you may have, during athletic team workouts if applicable to you, and any other activity you engage in throughout the week.

For Important Health Benefits
Adults need at least:2 hours and 30 minutes (150 minutes) of moderate-intensity aerobic activity (i.e., brisk walking) every week andmuscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest,  shoulders, and arms).1 hour and 15 minutes (75 minutes) of vigorous-intensity aerobic activity (i.e., jogging or running) every week andmuscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest,  shoulders, and arms). An equivalent mix of moderate- and vigorous-intensity aerobic activity andmuscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest,  shoulders, and arms).

10 minutes at a time is fine

We know 150 minutes each week sounds like a lot of time, but you don’t have to do it all at once. Not only is it best to spread your activity out during the week, but you can break it up into smaller chunks of time during the day. As long as you’re doing your activity at a moderate or vigorous effort for at least 10 minutes at a time.

How do you know if you’re doing light, moderate, or vigorous intensity aerobic activities? For most people, light daily activities such as shopping, cooking, or doing the laundry, don’t count toward the guidelines. Why? Your body isn’t working hard enough to get your heart rate up.

Moderate-intensity aerobic activity means you’re working hard enough to raise your heart rate and break a sweat. One way to tell is that you’ll be able to talk, but not sing the words to your favorite song. Here are some examples of activities that require moderate effort:

· Walking fast, doing water aerobics, riding a bike on level ground or with few hills, playing doubles tennis, pushing a lawn mover

Vigorous-intensity aerobic activity means you’re breathing hard and fast, and your heart rate has gone up quite a bit. If you’re working at this level, you won’t be able to say more than a few words without pausing for a breath. Here are some examples of activities that require vigorous effort:

· Jogging or running, swimming laps, riding a bike fast or on hills, playing singles tennis, playing basketball

Your plan should include:

1. Your name

2. Short term goal (goal for this term)

3. Long term goals (goals for a lifetime)

4. Using the F.I.T.T. principle map out your fitness plan using a table – don’t forget to include flexibility exercises (see example below). Your FITT plan should align with the minimum standards set by the CDC (see above).

Frequency(How often?)Intensity level(Heart rate?)Type(Activity?)Time(How long?)
5 days/weekvigorousRunning30 minutes
2 days/week3 sets of 12 – see muscle/muscle groupsWeights – free & machine45 minutes
3 days/week500 yards/15 minutesswimming15 minutes
2 days/week50% of maxvolleyball90 minutes
Everyday4 MPHdog walking30 – 60 minutes
Daily15 – 20 secondsYoga20 minutes
4 days/weekto muscle failureabdominal crunches15 minutes
1 day/weekmoderateHiking120 minutes

5. List specific muscle/muscle groups target areas for resistance training, for example: arms – biceps and triceps, chest, back, shoulders, abdominals, legs – (quadriceps, hamstrings, and calves). Make sure you include the number of sets and reps.

6. Now make a spreadsheet for the week and plug into each day when you are going to engage in each activity.

You will be graded on the thoroughness of your plan. This assignment is worth 10 pts. Please do not submit this assignment electronically.

Dietary Analysis

Name:Mohammed Alzaher
NutritionCaloriesCholesterol (mg)Sodium (mg)Protein (g)Fiber (g)Fat (g)Vitamin C (mg)Iron (mg)Calcium (mg)Carbohydrate (g)Sugars (g)Vitamin A (IU)
Thursday
BreakfastEgg Muffins681876260500.6250.60.6260
LunchChicken1926793609202010867812230117
DinnerBread with Cheese1132917470900.22020.40.1281
Friday
BreakfastChocolate Muffins373438351.11811.452613782
LunchMeet (Beef)21377612201302.215000
DinnerChicken Sandwich51568957244.8296.44.7603960
Saturday
BreakfastEgg Muffins681876260500.6250.60.6260
LunchFish Salmon412109117400277.70.7180099
DinnerBananas8901130141023121
Average Total/3days1147494.67808.67104.332.9771.3311.729.8136.3349.218.77366.67

Dietary Analysis

1. Record what you eat and the nutritive values for each item for three days (your three day period should include at least one weekend day and/or at least one week day). This should include each meal, snack, beverage, etc., and the number of servings consumed. At the minimum the analysis should include information regarding calories, carbohydrates, fats, protein, fiber, cholesterol, iron, calcium, sodium, sugars, and vitamins C and D.

To obtain nutritive values use your text, the nutrition facts label on the food container, or on-line resources such as: www.choosemyplate.gov,

www.wou.edu/student/residences/nutrition. There are also many free apps/websites available such as My fitness Pal and/or Lose It!.

2. Record and add up the nutritive values for each day. After the third day, compute a three day average for each nutrient. Now rate your diet by comparing your averages with those recommended by the United States Department of Agriculture (USDA):

http://fnic.nal.usda.gov/fnic/interactiveDRI/

3. Write a reflection page evaluating your three-day diet by answering the following:

What excesses and/or deficiencies do you see?

What changes in your diet might you recommend?

Any additional comments and impressions will only serve to increase or enhance your dietary analysis grade.

Each report must be word-processed. Correct spelling and grammar will be considered in the grading process. Attach your three-day diet record sheet as well as your nutritive averages to your analysisPlease read and follow the assignment directions carefully.

The implementation of evidence-based practice guidelines

Hindawi Publishing Corporation Nursing Research and Practice Volume 2012, Article ID 847626, 7 pages doi:10.1155/2012/847626

Research Article

Differences in Perceptions of Patient Safety Culture between Charge and Noncharge Nurses: Implications for Effectiveness Outcomes Research

Deleise Wilson, Richard W. Redman, AkkeNeel Talsma, and Michelle Aebersold

University of Michigan School of Nursing, Ann Arbor, 48109 MI, USA

Correspondence should be addressed to Deleise Wilson, wilsonsh@umich.edu

Received 4 October 2011; Revised 15 January 2012; Accepted 15 January 2012

Academic Editor: John Daly

Copyright © 2012 Deleise Wilson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The implementation of evidence-based practice guidelines can be influenced by nurses’ perceptions of the organizational safety culture. Shift-by-shift management of each nursing unit is designated to a subset of staff nurses (charge nurses), whom are often recruited as champions for change. The findings indicate that compared to charge nurses, noncharge nurses were more positive about overall perceptions of safety (P = .05) and teamwork (P < .05). Among charge nurses, significant differences were observed based on the number of years’ experience in charge: perception of teamwork within units [F(3, 365) = 3.52, P < .01]; overall perceptions of safety, [F(3, 365) = 4.20, P < .05]; safety grade for work area [F(3, 360) = 2.61, P < .05]; number of events reported within the last month [F(3, 362) = 3.49, P < .05]. These findings provide important insights to organizational contextual factors that may impact effectiveness outcomes research in the future.

1. Introduction

With the increasing emphasis in the efficient delivery of healthcare, healthcare organizations are investing in effec- tiveness outcomes research to improve patient outcomes. However, the uptake and implementation of evidence-based clinical practice guidelines are influenced by contextual fac- tors such as leadership support and use of change champions [1–3] and personnel perceptions of patient safety [4]. Within acute care settings, nurses’ perceptions of patient safety cul- tures and attitudes towards new practice guidelines are very critical for predicting the use of research evidence and new guidelines [5, 6]. What is known about nurses’ perceptions of patient safety culture has been reviewed in comparison with interdisciplinary team members [7–9] and across ranks such as staff nurses versus nurse managers [10]. Yet, staff nurses are not a homogenous group. In most acute care settings for each nursing unit, the management of each shift is designated to a nurse who then leads other staff nurses on that shift. The shift-by-shift leaders may be known as charge nurses, or assistant nurse managers [11, 12] and are often used as champions for change [13, 14]. Since nurses are very pivotal

to the implementation of safety guidelines, it is critical to have a deeper understanding of how these two groups of nurses, charge and noncharge nurses, perceive patient safety cultures. The purpose of this paper was to compare the perceptions of nursing units’ safety culture between charge nurses and staff nurses. For this study, the charge nurse is defined as a frontline nursing unit leader who makes shift- by-shift decisions about staffing, personnel and unexpected events that impact patient care [15]. In contrast, the non- charge nurse is defined as a staff nurse who is a direct patient care provider and has never had charge nurse experience.

2. Background

The creation of reliable healthcare organizations is funda- mental for the process of improving patient care [16, 17]. The use of evidence-based practice guidelines has become widespread as one of several methods healthcare organiza- tions seek to establish safe and reliable practice environments [18, 19]. Notwithstanding, there are many organizational barriers that limit the implementation of practice guidelines [20, 21]. Ricart et al. [22] found that nurses’ fear of potentialmailto:wilsonsh@umich.edu

2 Nursing Research and Practice

harm to patients contributed to nonadherence to evidence- based guidelines for the prevention of ventilator-associated pneumonia. Doherty [23] found that the lack of regular nursing staff educational meetings was a barrier to the implementation of adult asthma guidelines in the emergency room. Similarly, in the examination of the use of research in nursing organizations, Estabrooks et al. [5] stated that work and communication patterns characteristic of the nurses and the types of decision making processes predicted variability across organizations. Likewise, the positive perceptions of patient safety culture were associated with greater use of research findings and lower in adverse patient outcomes [2, 3, 24].

However, perceptions of patient safety culture vary across disciplines, healthcare settings, and professional ranks [25, 26]. Notably, leaders are often associated with having more positive perceptions of the safety culture than frontline workers, and managers and physicians generally reported higher levels of positive perceptions of safety as compared to staff nurses [27]. Singer et al. [28] found that among nurses, work experience and work position were significantly associated with perceptions of the patient safety culture. There were more positive reports from nurses who worked on a unit or hospital for more than 10 years, while Kim et al. [10] also found distinctions in perceptions of patient safety culture between staff nurses and managers among healthcare workers, but we would propose that this does not go far enough to examine potential differences between staff nurses and charge nurses.

At the nursing unit-level staff nurses function as either charge or noncharge nurses. Charge nurses generally func- tion as shift-by-shift leaders of nursing units whose duties may vary within and across organizations [29, 30]. Staff nurses tend to be recently hired, mainly provide direct patient care and are supervised by charge nurses [15, 31]. In the implementation of evidence-based practice initiatives, the nurses recruited as change champions can be either charge or noncharge nurses [32, 33].

Similar to findings about other contextual factors influ- encing effective outcomes research, the impact of opinion leaders is also multifaceted [6, 34]. Curran’s [35] study of opinions leaders indicated that the success of an opinion leader in leading change was influenced by acceptance of the role, developmental level of the social networks within organizations clarity of role expectations and perceptions of organizational context. Although positive perceptions of patient safety culture have influenced increased use of practice guidelines as reported by Estabrooks et al. [5] and Cummings et al. [2], there may be challenges to smooth implementation when confronted with differences in perceptions of organizational context experienced by change champions [36, 37]. To disentangle the effects of nurses’ perceptions of patient safety culture on the use of evidence- based practice guidelines, it may be necessary to determine whether differences in perceptions do exist between charge and noncharge nurses. With this need, this paper was aimed at exploring the differences in perceptions of safety culture between charge and noncharge nurses.

3. Methods

3.1. Design and Participants. This study used a descriptive, correlational and cross-sectional design to examine the differences in the perceptions of patient safety culture among registered nurses working in 12 adult medical surgical units at a large academic medical center in the Midwest. There were 710 registered nurses working in the 12 units at the time of the study. To be included in this study, the nurses had to have at least six months experience on their current unit and were supervised by a charge nurse or worked as charge nurse. LPNs and nurse managers were excluded from the study.

3.2. Data Collection. Following the approval of the institu- tional review board (IRB) of the medical center, a modified Dillman method was used to recruit nurses [38]. The design involved engaging the study participants in the following manner: (1) questionnaires in large manila envelopes were placed in staff nurses’ unit mailboxes; (2) 1-2 weeks after the study began, a thank you postcard was placed in the mailboxes to express appreciation for completion or as a reminder if the questionnaire had not been returned; (3) 3-4 weeks after, a thank you postcard was placed in mailboxes to express appreciation for completion of survey or as a gentle reminder if the questionnaire had not been returned. Completed surveys were placed in sealed drop boxes located within each nursing unit and sequentially numbered as they were returned. A total of 710 surveys were distributed. Over a 3-month period, 381 nurses returned completed questionnaires and signed consent forms, which yielded a response rate of 54%. Six of the 381 questionnaires were not used in the analyses on account of missing data that exceeded 10% of the total items in the study. The final sample, therefore, consisted of 375 respondents representing 53% of the total possible registered nurses who met the inclusion criteria.

3.3. Measures. The independent variables were charge nurse experience (no charge and some charge), percentage of shifts worked incharge in the past month (<25% and >25%), and number of years as charge nurse on current unit (none, less than 1 year, 1 to 5 years, and more than 5 years). Shift worked was a categorical variable with three options: permanent day, permanent night, and rotating shift. The demographic variables for the study were level of highest degree, length of time in current unit. The educational level options were (1) diploma and associate’s degrees; (2) baccalaureate degree; (3) master’s degree. Length of time in current unit response categories were (1) less than 1 year; (2) 1 to 5 years; (3) more than 5 years.

There were four dependent variables in the study, name- ly; overall perceptions of patient safety, number of events reported, teamwork within units, and safety grade. These dependent variables are four of the eleven subscales of the AHRQ Hospital Survey on Patient Safety Culture survey [39]. Researchers have found the AHRQ Hospital Survey on Patient Survey Culture to be reliable ranging from .72 to .84 with the exception of the staffing dimension (.63) [7]. In this

Nursing Research and Practice 3

study, the Cronbach alpha for overall perceptions of safety was .70, and teamwork within units was .80 [7]. Safety grade and number of events reported were single items.

3.4. Data Analysis. The statistical package for the social sciences (SPSS) software version 18.0.3 was used for analyses of the data. At the completion of data entry, there were fewer than 5% of missing items. Following the guidelines of McKnight et al. [40], this is below the 10% threshold. Therefore, the items were not deleted and were included in data analysis. Mean substitution done to impute the values for the missing items. t-tests were conducted to test the hypothesis that there were differences in patient safety culture between nurses with no charge and some charge experience. Pearson’s chi-square test was utilized to test the relationship between percentages of shifts in charge during the past month. ANOVA technique was utilized to examine differences in the perceptions of patient safety among nurses with varying percentages of shifts in charge and number of years as charge nurse during the past month.

4. Results

The descriptive characteristics of the study sample can be found in Tables 1 and 2. The sample of registered nurses consisted of 215 nurses with some charge experience and 159 without charge experience. Six out of ten of the nurses with no charge experience had a bachelor’s degree as compared to five out of ten of those with some charge experience. The nurses who were never in charge worked mainly during the rotating shifts (46%) with the least (17%) working the permanent day shift and 37% working the permanent night shift. A somewhat opposite pattern was noted in the nurses with some charge experience: 47% worked during the day; 31% at night; 22% percent worked as shift rotators. Of the nurses who were in charge, 47% worked on the current unit for more than six years compared to 12% of the staff nurses. Only 31% of the nurses functioned in the charge role for greater than twenty-five percent of shifts worked, while 25% were in charge for less than twenty-five percent of the shift worked, and the remaining 44% were never in charge. Interestedly, only 6% of the charge nurses self-identified as being permanent in the role in that they were in charge for 75% or greater of shifts worked. The educational preparation for those who were charge nurses was captured by number of shifts for shadow-charge orientation. Eight percent of the charge nurses stated they had no shadow-charge orientation. The majority (63%) of charge nurses had one to two shifts, while 29% had 3 or more shifts of shadow charge experience.

A two-tailed t-test for independent groups was used to test the hypothesis that the nurses with no charge and some charge experience will have differences in perception of safety. Significant differences were observed with two dimen- sions of the patient safety culture. The t-test revealed that for nurses with no charge experience the mean (3.46) for overall perception of safety was significantly higher than for the nurses with some charge experience (3.27), [t(374) = 2.86, P = .005]. Consistent with that finding, for the dimension

Table 1: Sample characteristics.

Variable Frequency

N Percentage

Shift normally worked (n = 333) Day 114 34.2

Night 113 33.9

Shift rotators 106 31.8

Number of years as registered nurse on current unit (n = 373)

Less than 1 year 33 8.8

1 to 5 years 220 59.0

6 or more years 120 32.2

Highest degree obtained (n = 375) Diploma and associate 144 38.4

Baccalaureate 205 54.7

Masters 26 6.9

Table 2: Charge nurse characteristics.

Variable N Percentage

Charge nurse experience (n = 374)

(1) some charge 215 57.5

(a) permanent charge 23 6.1

(b) relief charge 192 51.3

(2) no charge (staff nurse) 159 42.5

Percentage shifts worked incharge in the past month (n = 207)

<25% of shifts worked 92 44.4

>25% of shifts worked 115 55.5

Number of years as a charge nurse on current unit (n = 228)

Less than 1 year 30 13.2

1 to 5 years 114 50.0

More than 5 years 84 36.8

Shadow-charge orientation (n = 228)

None 17 7.5

1-2 shifts 144 63.2

3 or more shifts 67 29.4

number of events reported within a 12-month period, the nurses with some charge had a higher mean (2.31) than nurses with no charge experience (2.06), [t(368) = −3.35, P = .001]. These findings are summarized in Table 3.

The nurses with no charge experience reported fewer events. No events were reported by 21% of the nurses with some charge experience versus 14% of those with no charge experience. Of those who reported 1 to 2 events, 52% were reported by nurses with no charge experience as compared to 42% with some charge experience. As the number of events increased to 3 to 21 events, the nurses with some charge

4 Nursing Research and Practice

Table 3: t-tests for charge nurse experience and AHRQ perception of patient safety culture.

Outcome∗ No charge (n = 159) Some charge (n = 215)

Mean (SD) Mean (SD) t-value P∗∗

Overall perceptions of safety 3.46 (0.61) 3.27 (0.63) 2.86 .01

Number of events reported within the last 12 months 2.06 (0.70) 2.31 (0.70) −3.35 .01 ∗

Outcome was rated from 1 (strongly disagree) to 5 (strongly agree). ∗∗Two-tailed P value. Table only includes significant findings, full results can be obtained from corresponding author.

Table 4: Chi-square for charge nurse experience and AHRQ perception of patient safety culture.

Variable No event 1-2 events 3–21 events Total

None 32 (19.9) 84 (52.2) 45 (28.0) 161

Less than 25% 11 (12.2) 42 (46.7) 37 (41.1) 90

More than 25% 18 (15.7) 42 (36.5) 55 (47.8) 115

Total 61 168 137 366

X2(4) = 13.240; P = .010.

experience (45%) reported more events versus 27% of the nurses with no charge experience.

The Pearson’s chi-square test was utilized to test the relationship between percentage of shifts in charge during the past month and number of events reported in the past month. As shown in Table 4, fifty-two percent of the nurses with no charge experience reported 1 to 2 events; 20% reported no events; 28% reported 3 to 21 events. The nurses with no charge experience were almost equally divided between no events (20%) and 3 to 21 events (28%). The nurses with less than 25% of the shifts worked had the highest percent (47%) reporting 1 to 2 events, which is similar to the nurses with no charge experience. Moreover, 41% reported 3 to 21 events and 12% reported no events. Of the nurses who were in charge for more than twenty-five percent of shifts worked, 37% reported 1 to 2 events; 48% reported 3 to 21 events; 16% reported no events.

The nurses with no experience (20%) had a higher percentage of reporting no events as compared to the nurses with less than twenty-five percent of shifts in charge (12%) and more than twenty-five percent of shifts in charge (16%). The nurses who were in charge for greater than twenty-five percent of shifts worked reported 3–21 events three times more than they reported no events. In the category of 1 to 2 events, there was a higher percentage of nurses with no charge experience (52%) reporting as compared to the nurses with some experience. The nurses with some charge experience tended to report more events.

Utilizing ANOVA technique, differences in the percep- tions of patient safety among nurses with varying percentages of shifts in charge during the past month were significant differences in overall perception of safety, [F(2,369) = 3.27, P < .05]. Bonferroni’s post hoc test showed that there were differences between nurses with no charge nurse shifts and those with greater than 25% of shifts in charge in the last month.

There were also variations among the number of years as charge nurse for the perceptions of teamwork within units [F(3,365) = 3.52, P < .01], overall perceptions of safety,

[F(3,365) = 4.20, P < .05], safety grade for work area [F(3,360) = 2.61, P < .05], and number of events were reported within the last month [F(3,362) = 3.49, P < .05]. Further analysis using Bonferroni’s post hoc tests indicated the differences in perception of patient safety among the nurses with less than one year, one to five years and more than five years as charge nurse for teamwork within hospital units, the nurses with less than one year of experience were more positive than nurses with more than 5 years (P < .05). For overall perceptions of safety, the nurses who were never in charge had more positive perceptions of safety than those who were in charge for one to five years for more than 5 years (P < .01). The differences in safety grade for work area were between the nurses with no charge, who were more positive than the nurses with more than five years of charge experience (P < .05), and for the number of events reported within the last twelve months the nurses who were never in charge were more positive than those with one to five years of charge experience (P < .05).

5. Discussion

The purpose of the study was to evaluate whether differences in perceptions of safety exist between charge and staff nurses. Differences in perception of patient safety culture between and among charge nurses were established in this study. Specifically, we found that there were differences observed in perceptions of teamwork within the unit; overall perceptions of safety; safety grade for area; number of events reported within the last twelve months according to the number of years as a charge nurse. Nurses with no charge experience had more positive overall perceptions of patient safety, while the nurses with some charge experience had less positive overall perceptions of safety. Charge nurses with one to five or more than five years of experience were less positive about teamwork, overall perceptions of safety, safety grade for work area, and number of events reported. The percentage of shifts worked in charge in the past month provides more information about the differences observed between the

Nursing Research and Practice 5

charge and noncharge nurses. The results support differences in overall perception of safety between the nurses with greater than 25% of shifts in charge and with no shifts in charge. Chi-square tests for the patient safety grade for work area and charge nurse experience revealed no significant findings.

These findings run counter to the results from previous studies which indicate that there are less positive perceptions of patient safety by frontline nurses in general [7, 8]. Kim et al.’s [10] study about nurses’ perceptions of patient safety included 10% (n = 86) charge nurses, but they did not report findings that compared charge nurse perceptions of patient safety with those of other groups of nurses. Unlike Kim et al. [10], this current paper focuses on charge nurses as a discrete group. In a previous study, registered nurses in general with more experience and length of time on the unit were more positive about patient safety culture [10]. Other studies about perceptions of patient safety culture included nurses as a monolithic subset among healthcare providers such as physicians, clinical or nonclinical managers, and technicians [26]. In this regard, this current study marks an important departure from other empirical findings about role of leaders in perceptions of patient safety in health care organizations, especially as it pertains to nurses. This, in turn, may have important implications for how these leaders promote implementation of evidence-based practice as well.

In other findings, new graduates tended to make more medication errors [41] and are perceived to contribute more to errors than older, more experienced nurses [42]. Previous studies had also shown that new graduates were less positive about their work environment because they are more stressed adjusting to the work environment [43], emotionally exhausted [44], or overwhelmed [45]. However, the finding in this study that indicated the new graduates were more positive about perceptions of safety may be due in part, to observations that they may not have received adequate education about patient safety [46], may be more focused into developing critical thinking skills or their personal safety practices as against the demands of collective unit responsibility [47].

The differences in safety perceptions between nurses with no and some charge experiences may be explained by the fact that the charge nurses have a broader overview of potential and real safety errors and may be more familiar with the error reporting system or are more aware of the errors occurring on the unit than staff nurses, which influences their perceptions of patient safety adversely. Further, even differences noted among nurses who have charge experience. In a previous study, registered nurses with more experience and length of time on the unit were more positive about patient safety culture [10]. In this study, the more experienced charge nurses were less positive about patient safety culture. This may be indicative of a lack of full expertise by those who are in charge for less than 25% of shifts worked. Therefore, the nurses who move in and out of the charge nurse role and spend more time as a staff nurse than a charge nurse may share the same perspectives of the patient safety culture as staff nurses who were never in charge.

The charge nurse role is separate and distinct from the staff nurse role. Patient safety culture is perceived differently by charge nurses; isolating these differences may help to address the variations in nurses’ involvement in evidence- based practice guidelines. If the charge nurses are expected to serve as champion of change for effectiveness research initiatives, tailored educational approaches may be necessary based on their length of time as a charge nurse.

6. Limitations

First, this was a cross-sectional study, and the causal direction of the variables used in the study cannot be determined. Second, the study was conducted in a single, large academic medical center. The lack of designated charge nurse positions in this study setting made it difficult to truly test for differences in charge experience as nurses moved in and out of that role. Third, the use of a convenience sample is often associated with selection bias that may limit the generaliz- ability of the results. For example, a greater percent of nurses with a bachelor’s degree participated in the study. Future studies that use a probability sample design may increase the likelihood that the sample is representative of the population of charge nurses from which the sample was drawn.

7. Implications

Researchers and nurse managers who are interested in improving the safety culture and effectiveness research initiatives may benefit from assessments of the effects of contextual factors on implementation [48]. Understanding that differences in perceptions exist between nurses with varying levels of charge nurse experience may shed light on the mixed results found in the study by Rich et al. [49] about the use of opinion leaders and change champions for the uptake of practice guidelines. Proper training of healthcare team members is essential to develop effective partnerships for research implementation [50]. The success of utilizing evidence-based practice relies on the use of care providers members who serve to clarify program objectives and motivate colleagues [22, 50]. Nurse champions are most effective when the implementation strategy is tailored to meet the organizational contextual need [1]. The charge nurses were less positive than noncharge nurses about perceptions of patient safety culture. Charge nurses may be able to provide nuanced insights about the state of the patient safety culture, which can be explored further by including them in discussions about new initiatives. The effective use of charge nurses as change champions in implementation studies may necessitate their participation in the planning stages for the implementation of new practice guidelines and training about implementation strategies.

8. Conclusion

This study highlights the importance of charge and non- charge nurses’ perceptions of patient safety culture. Recog- nition of the importance of the charge nurse role in the

6 Nursing Research and Practice

assessment of patient safety culture may serve to improve the effective use of nurses as change champions. Future studies should assess the association of the implementation of evidence-based practice guidelines and perception of patient safety culture among nurses.

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  • Introduction
  • Background
  • Methods
    • Design and Participants
    • Data Collection
    • Measures
    • Data Analysis
  • Results
  • Discussion
  • Limitations
  • Implications
  • Conclusion
  • References

Preoperative Fasting: Knowledge and Perceptions

Preoperative Fasting: Knowledge and Perceptions

PATRICE BARIL, MS, RN, CNOR; HARRIET PORTMAN, BSN, RN, CAPA

Optimal surgical, anesthesia, andnursing outcomes depend onadequate patient preparation. Preoperative fasting is an essential ele- ment of the patient preparation pro- cess. The goal of fasting is to empty the stomach, thereby reducing the risk of aspiration of stomach contents during the anesthetic period.

Before 1999, the traditional, general guideline for preoperative fasting was that patients should be NPO after mid- night on the day of surgery. In 1999, after examining rele’ant research find- iiigs, the American Society of Anesthesi- ologists (ASA) released new, more lenient preoperative fasting guidelines for healthy, nonpregnant patients. The new guidelines called for preoperative fasting from clear fluids for two hours before any procedure that requires seda- tion or anesthesia as well as fasting from solid foods for at least six hours before anesthesia or sedation is administered. The ASA recommends that these guide- lines be modified for any patient with a condition that affects gastric emptying as well as for patients with potential air- way management issues.’

At a community hospital near Boston, Massachusetts, one staff RN in the Pread- mission Testing area became aware that surgical patients at the facility seemed to be fasting for excessive lengths of time, a perception that was echoed by other perioperative nurses on staff. The hospital was beginning its journey toward Magnet status, and hospital administrators were implementing a nursing research and clinical inx’estigation program. At the urging of the director of nursing staff development and nursing research, the staff RN who had originally identified the problem and a clinical nurse special-

ist in the Surgical Services Department decided to conduct a clinical investiga- tion of preoperahve fasting at this facility. The pLirpose of fhis clinical project was to determine whether patients were fasting excessively and, if so, to explore the atti- tudes and beliefs of surgical patients and their care providers to determine why patients still fast excessively despite re- search findings advocating shorter pre- operative fasting periods and updated fasting guidelines from the ASA.

LITERATURE REVIEW

Many anesthesiologists have changed their practice and no longer require the traditional eight-hour fast before elective surgery. In a national survey of 1,337 ASA members, 94% of the respondents were aware of new literature recom- mending shorter fasting periods before elective surgery, and 68% of those had changed their practice.-

ABSTRAQ PREOPERATIVE PATIENT EASTING is an essential element of the patient preparation process, but pa- tients may be fasting for excessive lengths of time.

INVESTIGATORS AT ONE FACILITY used semi- structured interviews to explore the knowledge and beliefs of patients, nurses, and anesthesia care providers regarding the practice of preoperative patient fasting.

FINDINGS INDICATE that some patients had excessive fasting times, and practitioners had erro- neous perceptions about patient knowledge regard- ing the rationale for fasting and compliance with instructions. Clinicians expressed concern about the effects of excessive fasting but were reluctant to relax the policy. AORN} 86 (October 2007) 609- 617. © AORN, Inc, 2007.

. lnc.2f)07 OCTOBER 2007, VOl 85, NO 4 • AUIÍN lOUkN.-M • 6 0 9

OCTOBER 2007, VOL 86, NO Baril — Portman

One reason for excessive preoperative

patient fasting could be related to a

general mistrust on the part of

practitioners that patients will

understand and comply with their

fasting instructions.

Pandit et aP studied the practices of anesthesi- ologists in the United States and found that 627(1 of participating anesthesiologists had an institu- tional policy in place that allowed patients to ingest clear liquids two to three hours before elective surgery. Thirty-five percent of partici- pants allowed patients to ingest a light breakfast six hovirs before surgery. The researchers deter- mined that the key factors affecting how long patients fast include hospital policy, nurse and anesthesia care provider kiiowledge of current research findings, and patient education regard- ing the length of and rationale for fasting.

Lengthy preoperative fasts have been com- mon. Crenshaw and Winslow^ found that pa- tients fasted for an average of 12 to 14 hours, with some fasting for more than 20 hours. Tra- ditional preoperative fasting instructions (ie, NPO after midnight) were common practice at the time their study was undertaken. Pearse and Rajakulendran’̂ also found excessive fast- ing times in their study. The average fasting time was 12 to 14 hours with an overall range of 4.5 to 20 hours. It appeared that patients were beginning the preoperative fast long before the instructed time.

The literature also revealed several possible reasons for excessive preoperative fasting. One reason is that there seems to be a general mis- trust on the part of practitioners that patients will understand and comply with a fasting policy. One study found that anesthesiologists and surgeons believed that if patients were told that they could ingest clear liquids, they

might also consume solid foods.* Patients’ lack of knowledge regarding the

rationale for preoperative fasting is another factor that may contribute to excessive fasting. Chapman’ found that 85″^ of surgical patients received no explanation for fasting, SI”/» were unaware of the reason for preoperative fasting, and 50% thought the reason for fasting was to reduce vomiting. Only 187« of patients associ- ated vomiting with possible aspiration of gas- tric contents. In addition, Hung’̂ found that surgical patients not only did not know the reason for preoperative fasting, but they also were not comfortable asking their health care providers about it because they did not want to be perceived as demanding.

Another possible reason for lengthy fasting times is concern about rapidly changing surgi- cal schedules. In a study by Green et al,*” anes- thesiologists cited the economic impact of delays and cancellations on the surgical sched- ule as a reason for their reluctance to relax fast- ing guidelines.

An additional factor that contributes to ex- cessive fasting times may be related to health care facilities’ policies on fasting. The absence of a formal fastüig policy or staff members’ inade- quate knowledge of the policy has been found to affect fasting times.”‘” Chapman” interviewed anesthetists, surgical nurses, and patients scheduled for elective surgery regarding their knowledge of recommended preoperative fast- ing guidelines. In the study facility, there was no formal policy for preoperative fasting, and the average fasting time was 11 hours. Half of the anesthetists were aware of current research findings and recommended two- to three-hour liquid fasts; however, participating nurses were unaware of these findings. Chapman attributes the nurses’ knowledge deficit to the fact that at the time her study was performed, most of the published research regarding preoperative fast- ing appeared in medical journals rather than nursing journals.”

Seymour” conducted a study of nurses and anesthetists to assess their knowledge of hospital policy. She reported that less-experienced physi- ciaiis and nurses did not realize that the hospital had a preoperative fasting policy, but 50% of sen- ior nurses and all anesthesia attending physicians

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Bari! — Portman OCTOBER 2007. VOL 86, NO 4

were aware of the policy. Patients at this facility still fasted excessively, however, with fasting times ranging from 3.5 to 17.75 hours.

Excessive fasting can lead to patient dis- comfort and may even increase morbidity of surgical patients.” Some researchers suggest that the ritualistic approach to preoperative fasting be reevaluated through collaboration between nurses and anesthesia care providers to allow for more flexible fasting instructions based on current research findings.”‘”

PARTICIPANTS

A clinical investigation was conducted at a 200-bed community hospital in a suburb north of Boston. The project participants included anesthesiologists, certified registered nurse anesthetists (CRNAs), registered nurses, and surgical patients. All anesthesia care providers im the permanent staff as well as RNs working in the Preadmission Testing Department, Day Surgery Department, and OR were eligible for inclusion in the project. The patient population included men and women with no history of cognitive deficits who were scheduled for elec- tive surgery and had an ASA Physical Status Classification score of 1 or 2. An ASA score of 1 indicates a normal, healthy patient whose only medical problem is the condition for which surgery is being per- formed. An ASA score of 2 indicates a patient who has at least one medical condition that is under control and does not pose a significant threat to his or her health.”

PROCEDURE

The investigators developed a series of open-ended inter- view questions that they asked oí eligible patients (n = 34), nurses (n – 15), and anesthesia care providers (n = 12). The content of these interview questions was based on empir- ical data found during the liter- ature review. All participants signed a consent form inform-

ing them of the investigators’ intent to tape- record the interviews, and they were given assurances of confidentiality. Patients were interviewed on the day of surgery either preop- erativeiy or postoperatively. Nurses and anes- thesia care providers were interviewed at a time that was con’enient for them.

All interviews were tape-recorded and tran- scribed word for word. The investigators then analyzed the transcripts to identify themes and major ideas. Tlie tapes and transcripts were kept in a locked area at all times and were destroyed after the data were analyzed.

FINDINGS

The average length of the preoperative fast in this clinical project was similar to those noted in the studies performed by Crenshaw and Winsiow^ and Pearse and Raja ku lend ran,’ both of which found an average patient fasting time of 12 to 14 hours, with some patients fast- ing as long as 20 hours. Patients in the current clinical investigation reported fasting for five to 23 hours before surgery, with a mean fasting time of 11.70 hours. Sixty-seven percent of patients fasted for at least 12 hours, and 50% fasted for more than 14 hours (Figure 1).

Time spent fasting

Figure 1 • Length of preoperative fasting times for patient participants.

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OCTOBER 2007, VOL 86, NO 4 Baril — Portman

The participants voiced many recurring ideas related to preoperative fasting during the interviews. These included • practitioner concerns about patient compli-

ance with instructions, • confusion among practitioners regarding

who is responsible for instructing patients about the preoperative fast,

• knowledge deficits among patients regard- ing the rationale tor fasting,

• knowledge deficits among practitioners regarding hospital policy on preoperative fasting, and

• practitioner concerns that patients would be confused if allowed to consume clear liq- uids before surgery. 11

From the many different ideas , i that emerged from the inter- ‘ views, the investigators iden- tified three overarching themes: perceptions, safety concerns, and knowledge.

PERCEPTIONS

One overarching theme the investigators identified was practitioners’ perceptions re- garding patients’ knowledge about why they need to fast, the extent to which patient noncompliance with fasting affects the surgical schedule, and the effectiveness of the current hospital fasting policy. The interviews revealed that anesthesia care providers’ and nurses’ perceptions were simi- i [ lar on some topics but differed on others.

PATIENTS’ KNOWLEDGE ABOUT FASTING. Anesthesia care providers’ perceptions demonstrated a belief that patients lacked sufficient knowledge about the preoperaHve fasting process. One anesthesia care provider commented, “I think most patients have no clue why they have to fast.” Another stated, “I don’t think they understand NPO.”

The nurses believed that patients either do not understand the instructions given to them or are not given proper instructions to begin

Both nurses and

anesthesia care

providers expressed a

belief that patients

da not know or da not

understand why

they need ta fast

preaperatively.

with. One nurse said, “T don’t think anyone explaiiis to them why they have to be NPO after midnight. I think they tell them not to eat anything, but don’t tell them the importance of not eating.” Another nurse commented,

Ma/be they don’t understand what is told to them because they don’t understand their preoperative instructions. They just don’t believe that they have to fast and why they have to fast.

ALTERATIONS TO THE SURGICAL SCHEDULE. Another perception practitioners voiced was a belief that the surgical schedule is altered markedly by patients’ noncompliance with preoperative

fasting instructions. One anesthesia care provider said, “I think we have about 10% who don’t comply with in- structions.” Another noted, “Patients are more comfort- able when they don’t have to be totally NPO, but at the same time, it affects us; some- times the surgery can get cancelled.”

Nurses also believed that lack of compliance with fast- ing instructions can alter the surgical schedule. One nurse noted, “If they’re not instruct- ed properly, it’s not going to work well because they’re going to drink at the wrong time and then foul up the time schedule here.” Another participant said, “It’s for the hospital OR’s benefit to keep

things moving. It’s better for them to have everybody NPO overnight.”

Some anesthesia care providers expressed a preference for having flexibility in the surgical schedule to accommodate last minute changes, which may only work if patients have been fast- ing. One participant stated, “It would be nice if they could have clear liquids, but if the case gets changed, and they get called sooner, then it would interfere.” This sentiment was echoed by another anesthesia care provider, who said.

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0CT08ER 2007, VOL 86, NO 4 Bari] — Portman

There is a trend toward giving people a light breakfast in the morning. The problem with that is if your case gets moved up earlier in the day, the patient is denied that spot; and in this institution, when we zoork at such a high pace, that can happen frequently, and it ends up tying it up. So we made a conscious decision not to do that here.

One anesthesia care provider voiced a per- ception that procedures needed to be can- celled or rescheduled 10″/) to 15’X. of the time. In fact, during the six-month data collection period, the actual rate of cancellations due to insufficient preoperative fasting was 0.11% according to the cancellation log. This log, however, only captures cancellations, not patients delayed until later in the day to ac- commodate a short fasting time, and therefore may not adequately reflect the impact on the surgical schedule of patients who are noncom- pliant with fasting instructions.

HOSPITAL FASTING POLICY. At the time this project was undertaken, the hospital fasting policy called for patients to be NPO after midnight with clear liquids allowed in healthy, nonpreg- nant patients up to six hours before surgery. Perceptions differed among practitioners re- garding how well the current hospital policy was working. One nurse voiced the comment, “It’s not working well because each anesthesiol- ogist decides what they’re going to do.” Anoth- er said, “It’s one policy, and it’s supposed to be followed by everyone, but then there are varia- tions depending on the anesthesia person.”

One CRNA noted, “It fluctuates to the point that the surgeon went from one anesthesiolo- gist to another to try to find someone to relax [the policy].” An anesthesiologist stated,

/ think our policy is a little bit flexible so that patients can be moved up, which is important; so that is one way our policy works well. Con- sistency is important because if the nurses have lo give out different policies for different patients, there’s always confusion.

Nurses and anesthesia care providers also were asked their opinion on what the ideal hos- pital policy should be. Nurses expressed the

need for more individualized instructions ac- cording to the time of surgery. One nurse said.

If the patient is having surgery at 5 o’clock in the afternoon and they are fasting since mid- night, IthatJ is way too long. If the surgery is at 7 AM, they can have food at midnight; if thei/ are having surgeiy at 5 PM, ivhy can’t thei/ have food six hours prior to their surgery? Wliat dijference does it make if they are sleeping or not? It just doesn’t make sense to me.

Another nurse stated.

It depends on the time of the patient’s surgery; it should not be “after midnight.” Some patients’ surgery is at 4 o’clock; it should be like eight hours before the surgery. It’s hard; it’s easier just to say, ‘nothing after midnight’ to everybody.

Anesthesia care providers’ responses re- garding the ideal hospital fasting policy varied widely. Among aiiesthesia care providers, • 50% wanted no change to the current hospi-

tal policy; • 25% wanted the policy to become more rigid,

changing to flat NPO for eight hours before surgery with no difference regarding guide- lines for ingesting liquids or solids; and

• 25% wanted to make the policy more liberal in some way.

One anesthesia care provider wanted to fully comply with ASA recommendations, allowing patients to ingest clear liquids up to two hours before surgery and light solids four to six hours before surgery. The other anesthesia care providers who thought the policy should be more liberal wanted to change it for specific populations, with one citing pédiatrie patients and the other citing “minor surgery” patients as the patients who should be allowed more liberal fasting guidelines.

SAFETY CONCERNS Anesthesia care providers and nurses were

asked what they thought patients cared about as well as what they, as practitioners, were concerned with in regard to preoperative fast- ing. The practitioners seemed to believe that

6 1 4 • AORISI JOURNALwhen the report includes participant comments it indicate qualitative

Baril — Portman OCTOBER 2007, VOL B6, NO 4

patients were not concerned about the conse- quences of not following the instructions for tasting. One anesthesia care provider stated, “I don’t think NPO is very important to them. . . . 1 think comfort is more important to them.” Acciirding to another participant, “They all want to eat. They don’t care about anything. They don’t know the risks.” One nurse stated, “In some instances, 1 think they just disregard [the instructions!; they’re get- ting their kid ready for school, anci they just grab something [to eat].”

Although the patients could not

articulate a concrete rationale for

preoperative fasting, most knew on

some level that surgery, anesthesia,

and a full stomach do not mix.

When asked about their main concerns re- garding preoperahve fasting, nurses responded that they were concerned about the potential for adverse effects of prolonged fasting, such as dehydration, nausea and vomiting, and caffeine withdrawal headaches. One nurse said, “I think the longer a patient fasts, the more problems they would encounter, dehydration during the summer, and nausea and vomiting for long NPO status.” According to another nurse,

/ think that where surgeries are getting shorter, I think that the patients are in the OR for a shorter period of time and that they are hi/drated less. I think ive see a lot more dclu/drution; along with that we see some headaches. I think we see nausea front lack of solid food more frequenthf.

Anesthesia care providers stated that their concern is the safety and comfort of their

patients. The primary concern for one was “Safety—you want to know that the stomach is empty so that the patient doesn’t aspirate.” Another noted, “Their safety is of prime im- portance, and their comfort.” According to a third participant.

There’s a movement going on in our societi/ to try and he as relaxed as possible on NPO because it is uncomfortable and inconvenient for the patients, but you have to draw the line on patient safety. A lot of times the patients, nurses, or surgeons don’t understand that we’re really dohig this for the patient’s safety and not just because of some guideline.

KNOWLEDGE

Another main theme the investigators identi- fied from the interviews involved patients’ and practitioners’ knowledge in relation to preopera- tive lasting. This included patients’ and practi- tioners’ knowledge regarding the rationale for Fasting as well as practitioners’ knowledge of the guidelines for preoperative fasting.

KNOWLEDGE OF RATIONALE FOR FAsnNG. Contrary to the beliefs of nurses and anesthesia care pro- viders, patients consistently identified a ration- ale for fasting that was not entirely erroneous. Of the patient participants, 82’/o had some idea of the rationale for preoperative fasting.

Wiien patients were asked why they needed to be NPO, they were not able to articulate a con- crete rationale; most patients, howe’er, knew on some level that surgery, anesthesia, and a full stomach do not mix. One patient said, “You can exasperate [sic] if you have stuff in your stom- ach.” Another stated, “1 don’t know the reason. I would assume it has something to do with the anesthesia.” According to a third patient, “You could throw up and choke on your own vomit.” Another patient said,

/ understand that you have no food in your stomach so you could possibly, I don’t know, have a reaction to anesthesia, or it could somehoiv cloud ivliatever they need to look at.

Anesthesia care providers and nurses also were asked what they believed to be the ration- ale for prooperative fasting. The anesthesia care

AORN JOURNAL» 6 1 5

OCTOBER 2007, VOL 86, NO Baril — Portman

providers all were able to identify the potential for aspiration with increased risk of pneumonia as the rationale for patients’ fasting before sur- gery. Of the nurses surveyed, 7y% cited aspira- tion and its potential complications as the rationale for preoperative fasting.

GUIDELINES FOR FASTING. Nurses and anesthesia care providers were asked about their knowl- edge of the current hospital policy on preoper- ative fasting as well as the guidelines used by the ASA. Of the participants, 66% of nurses and 8′)o of anesthesia care providers could articulate the hospital policy. The exact ASA guidelines were known by y% of nurses and 16% of anesthesia care providers who were surveyed (Figure 2). ^

LIMITATIONS AND AREAS FOR FUTURE STUDY

This clinical investigation was limited in that it was a survey of participants at a single site and included a relatively small sample size. The findings of this project reflect only

Knowledge of hospital policy

Knowledge of American Society of Anesthesiologists guidelines

Staff members

Figure 2 • Percentage of nurses and anesthesia care providers

who know the hospital policy and the American Society of

Anesthesiologists guidelines on preoperative fasting.

the thoughts and opinions of clinicians and patients from this sample and cannot be gener- alized as representative of the opinions of anesthesia care providers, perioperative nurs- es, or patients at other facilities.

A formal, qualitative research sti.idy on this topic may reveal more generalizable trends as well as factors to be researched in the future. The nature of qualitative research is defined by the in-depth study of a phenomenon. This type of research is not intended to prove anything, but to explore an issue in a thorough fashion.

Potential areas for future research may in- clude how individualizing the fasting policy to the patient affects compliance with the policy as well as what effect a policy change may have on the flow of the surgical schedule. Another possi- ble area for research is a correlation between the amount of time surgical patients fasted and their postoperative symptoms, such as headache, nau- sea, vomiting, and dehydration.

THE NEED FOR CHANGE

Preoperative fasting remains a confusing concept for patients and a source of frustration for practitioners. Hospitals and ambulatory surgery centers need sensible preoperative fasting policies that reflect current research findings. Anesthesia care providers, surgeons, and nurses must collaborate to create and enforce policies that are safe for patients undergoing surgery and accepted by all practi- tioners. Personnel providing instruction to patients must have a clear knowledge of the facility’s fasting policy. In some instances, staff members at a surgeon’s office, who may not be aware of the rationale for fasting or the impli- cations of excessive fasting, provide the preop- erative instructions. To protect the patients’ well-being, hospital nursing staff members must be aware of what patients are being told and who is telling it to them. Patients must be given clear preoperative instructions that explain the rationale for and importance of preoperative fasting.

This project demonstrated that patients are more likely to fast for an excessive rather than insufficient amount time before surgery. The investigators presented their findings from this project, the current ASA recommendations, and

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Baril — Portman OCTOBER 2007. VOL 86, NO

findings from other research studies at surgeon and anesthesia committee meetings at their facility. Tliis led to a change in the hospital fast- ing policy. Although patients still are required to fast from solid foods after midnight on the day of surgery, they now are allowed to ingest clear liquids up until four hours before their scheduled surgery. The new fasting policy does not fully reflect the ASA recommendations because there still is a high level of concern among anesthesia care providers about keeping the surgical schedule flexible.

Fasting excessively has been shown to in- crease the discomfort and possibly the morbid- ity of surgical patients.” To minimize risks associated with insufficient or excessive fast- ing, patients must have a clear understanding i>f the rationale for fasting and the potential ad’erse effects of excessive fasting. Optimal surgical, anesthesia, and nursing outcomes depend on it. –

Acknozi’ledgement: Tlie ant¡iors thank tlieir men- tor, Kathleen Bei/erman, EdD, RN, CNA, director of nursing research atui nursing staff development, Winchester Hospital, Winchester, MA, for her expertise and guidance.

REFERENCES 1. Practice guidelines for preoperative fasting ¿ind the use of pharmacologie agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedLires: a report by the American Society of Anesthesiologists Task Force on Preoperati’e Fasting. Anesthesiology.

2. McKinley AC, james RL, Mims GR 3rd. NPO after midnight before elective surgery is no longer common practice for the majority of anesthesiolo-

gists. Am / Aucsthciiiol. 1’í95;22(2):88-92. 3. Pandit SK, Loberg KW, Pandit UA. Toast and tea before elective surgery? A national survey on cur- rent practice. Am-sth Ámüg. 2000;90(6):l348-1351. 4. Crenshaw JT, Winslow EH. Preoperative fasting: old habits die hard. Am ¡ Nurs. 2n02;102(5):36-44. 5. Pearse R, Rajakiilendran Y. Pre-opcrative fasting and administration of regular medications in adult patients presenting for elective surgery. Has the now evidence changed practice? Eur } Anaesthesiol. 1999;]6(8):%5-568. 6. Murphy GS, Ault ML, Wong HY, Szokol JW. The effect of a new NPO policy on operating room uti- lization. / Clin AncstlL 200b;12(l):48-51. 7. Chapman A. Current theory and practice: a study of pre-operative tasting. Nurs’stmui. 1996;10(18):33-36. 8. Hung P. Preoperative fasting. Niirfi Times. 1992;88 (48}:57-6Ü. 9. Green CR, Pandit SK, Schork MA. IVeoperative fasting time: is the traditional policy changing? Results of a national survey. Anestti Anal^. 1996;83 (1):123-128. 10. Seymour S. Preoperative fluid restrictions: hos- pital policy and clinical practice. Br } Nurs. 2000; 9(14):925-930. 11. Napoli M. Preoperative fasting: rules changed. HfoltliFact^. June 2Ü02. http://www.medicalconsu mers.org/pages/newsletter__excerpts.html. Accessed July 11,2007. 12. ASA Physical Status Classification System. American Society of Anesthesiologists, http:// www.astihq.org/clinical/physicalstatus.htm. Ac- cessed July 11, 2007.

Patrice Baril, MS, RN, CNOR, is the nurse manager of the OR at Winchester Hospital, Winchester, MA.

Harriet Portman, BSN, RN, CAPA, is a staff RN, Preadmission Testing, at Winches- ter Hospital, Winchester, MA.

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Presentation on diabetes

Imagine you are a community health educator and you have been tasked with developing a presentation to be given in a setting to educate an audience on one type of diabetes.

Identify your audience. Examples include the following:

  • Senior center
  • Middle school
  • A workplace

Create a resource (350 to 600 words) as a way to share this information. Examples include the following:

  • A social media page
  • An information pamphlet
  • A presentation

Consider the best method so it is crafted in an appropriate and understandable way for your identified audience.

Choose from the two following options:

Option A: Type 1 Diabetes

  • How society views Type 1 diabetes (what society thinks it is versus what it actually is, common beliefs and practices)
  • Signs and symptoms
  • Compliance with treatment regimens
  • Making the right decisions to live a healthy life
  • Impact on health care resources

Option B: Type 2 Diabetes

  • How society views Type 2 diabetes (what society thinks it is versus what it actually is, common beliefs and practices)
  • Preventive measures
  • Signs and symptoms
  • Making the right decisions to live a healthy life
  • Compliance with treatment regimens
    Impact on health care resources

APA Cite sources Minimum 2

Hypertension Case Study


D. G. is a 54-year-old African American male who comes into the clinic for a “blood pressure check”. He states that his previous physician told him that his blood pressure was high and too loose weight. He was supposed to follow up in four weeks but did not return to the clinic. His current blood pressure is 172/92. D.G. states that he feels fine and does not have time to exercise.

PMH

-hyperlipidemia

-hypertension

-surgical repair for broken ankle (7 years ago)

FH

Father died of heart disease at age 80, but his first MI was at 44; mother died at age 68 and had HTN and diabetes; brother (age 50) has HTN and high cholesterol; younger sister (age 42) has diabetes and HTN.

SH

He has been married for 30 years and has 1 daughter and 1 son who are healthy. He is a current smoker 1 ppd for 20 years. He occasionally drinks alcohol (1-2 drinks per week). His diet consists mainly of fast food and starchy carbohydrates. D. G. likes to drink regular soda pop

Meds

-Simvastatin 20 mg every evening

-Acetaminophen 500 mg as needed for pain

ALL

-NKDA

VS

BP 172/92, HR 80, wt 250 lbs., 6” ft. 5”

Questions: Please read all of the questions before answering. Your references should be from the textbook, clinical or evidenced based guidelines, or peer reviewed journals. Points will be deducted for references that are not from the above sources.

1. Define the patient’s problemRefer to chapter 3 Rationale for prescribing

5pts

2. What is the therapeutic objective for treating this patient? 5pts

3. The patient has already been diagnosed with hypertension. What are his risk factors (modifiable and non-modifiable for cardiovascular disease)? 5pts

4. List the goals of treatment for this patient. This is different from question 2

5pts

5. What nonpharmacologic therapies are necessary for this patient to achieve and maintain adequate blood pressure reduction? 5pts

6. What reasonable pharmacotherapeutic options are available for controlling this patient’s blood pressure? 5pts

7. Outline a specific and appropriate pharmacotherapeutic regimen for this patient, including:

a. Drug name, dose & dosage, form, route, regimen, duration and purpose.

b. Identify the medication classification

c. Mechanism of action

d. Major adverse effects and side effects

e. Contraindications

f. Safety alerts and precautions

g. Determination of clinical efficacy 15pts

8. What clinical guideline/standard of practice guidelines support your medication selection?

State the specific clinical guideline used.

How do these guidelines relate to your patient?

Include dosage, patient variables, follow up, diagnostic tests, and maintenance regimens.

10pts

9. Outline specific lifestyle modifications for this patient. 5pts

10. Based on your recommendations, provide appropriate education to this patient. Include how you would assess the patient’s level of understanding.

10pts

Clinical Course

DG two month follow up appointment, he states that he has been walking 2 miles a day, and has been adherent to his medications as prescribed He states that he is having difficulty with healthy eating. His average blood pressure is 140/82.

11. What instructions should you give the patient at this point in his therapy. 5pts

12. What changes in therapy would you recommend if the patient now complains of intolerable adverse effects due to the current antihypertensive drug therapy. Outline an appropriate change to his current therapyInclude rationale and clinical guideline used to support the change.

10pts

13. What changes in therapy would you recommend if the patient is tolerating the current drug therapy but had not achieved the desire BP control (average BP162/88)? Outline an appropriate change to her current therapyInclude rationale and clinical guideline used to support the change.

10pts

Use of APA format to cite sources and references 5pts

Define the patient’s problem.

5pts

The prevalence of hypertension is high in the United States and worldwide, and treatment of hypertension is the most common reason for office visits of nonpregnant adults to clinicians in the United States and for use of prescription drugs. In addition, roughly half of hypertensive individuals do not have adequate blood pressure control

Hypertension — The following definitions and staging system, which are based upon appropriately measured blood pressure , were suggested in 2017 by the American College of Cardiology/American Heart Association (ACC/AHA); proper measurement technique, which is detailed below, is of paramount importance when identifying patients as having hypertension:

Normal blood pressure – Systolic <120 mmHg and diastolic <80 mmHg

Elevated blood pressure – Systolic 120 to 129 mmHg and diastolic <80 mmHg

Hypertension:

Stage 1 – Systolic 130 to 139 mmHg or diastolic 80 to 89 mmHg

Stage 2 – Systolic at least 140 mmHg or diastolic at least 90 mmHg

If there is a disparity in category between the systolic and diastolic pressures, the higher value determines the stage. Isolated systolic hypertension is defined as a blood pressure ≥130/<80 mmHg, and isolated diastolic hypertension is defined as a blood pressure <130/≥80 mmHg. Patients with a blood pressure ≥130/≥80 mmHg are considered to have mixed systolic/diastolic hypertension.

Mr G a 54 years old African American male with a history significant for Hyperlipidemia, hypertension presented to the clinic with a blood pressure of 172/92 and asymptomatic. According to ACC/HA, he has a stage 2 Hypertension. And seemed to be non compliant with his management regimen including diet and exercise . He obviously needs to be on anti hypertensive medication. But one this however is to focus on what medication will be most effective According to (Woo , 2016), WHO recommends a proper diagnosis prior to prescribing any medication is the first step , a determination of the therapeutic goal and objectives . Having these factors in mind, it is important that Mr has a clear knowledge of the treatment plan and encouraged to participate in the selection options available to optimize compliance.

What is the therapeutic objective for treating this patient? 5pts

The therapeutic objectives for treating Mr G are to prevent the occurrence of cardiovascular disease due to damage to the heart and blood vessels caused by sustained high blood pressure, and consequent functional impairment and death. In patients who have already developed cardiovascular disease, treatment is aimed at preventing progression or recurrence, reducing mortality and, thus, helping patients with hypertension to lead their lives as do healthy people.

The higher the risk of cardiovascular disease, the greater the effect of hypertension treatment.The results of randomized case–control comparative studies provide the best scientific basis for evaluating the effects of antihypertensive treatment (lifestyle modifications and drug therapy). However, the effects of antihypertensive drug therapy are often underestimated in randomized case–control comparative studies, and the duration of such studies is only a few years, whereas hypertension is treated over a lifetime. Therefore, the significance of the results of randomized case–control comparative studies is limited. ( )

The patient has already been diagnosed with hypertension. What are his risk factors (modifiable and non-modifiable for cardiovascular disease)? 5pts

Hypertension is associated with a significant increase in risk of adverse cardiovascular and renal outcomes. Each of the following complications is closely associated with the presence of hypertension

Left ventricular hypertrophy (LVH)

Heart failure, both reduced ejection fraction (systolic) and preserved ejection fraction (diastolic)

Ischemic stroke ,Intracerebral hemorrhage , ischemic heart disease, including myocardial infarction and coronary interventions)

Quantitatively, hypertension is the most important modifiable risk factor for premature cardiovascular disease, being more common than cigarette smoking, dyslipidemia, or diabetes, which are the other major risk factors. Hypertension often coexists with these other risk factors as well as with overweight/obesity, an unhealthy diet, and physical inactivity. The presence of more than one risk factor increases the risk of adverse cardiovascular events.

The likelihood of having a cardiovascular event increases as blood pressure increases. In a meta-analysis of over one million adults, risk began to rise in all age groups with blood pressures greater than 115/75 mmHg . For every 20 mmHg higher systolic and 10 mmHg higher diastolic blood pressure, the risk of death from heart disease or strokes doubles.

The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for the management of hypertension summarized the available meta-analyses of observational data by comparing the cardiovascular risk of different blood pressure strata with a reference group that had a blood pressure <120/80 mmHg. A blood pressure of 120 to 129/80 to 84 mmHg was associated with a hazard ratio of 1.1 to 1.5 for cardiovascular events, and blood pressure of 130 to 139/85 to 89 mmHg was associated with a hazard ratio of 1.5 to 2.0. This relationship was consistent across sex and race/ethnic subgroups but was somewhat attenuated among older adults.

The prognostic significance of systolic and diastolic blood pressure as a cardiovascular risk factor appears to be age-dependent. The systolic pressure and the pulse pressure are greater predictors of risk in patients over the age of 50 to 60 years . Under age 50 years, diastolic blood pressure is a better predictor of mortality than systolic readings . Systolic hypertension and pulse pressure in older individuals are discussed in detail separately.

While hypertension is associated with a relative increase in cardiovascular risk regardless of other cardiovascular risk factors, importantly, the absolute risk of cardiovascular risk is dependent on age and other cardiovascular risk factors in addition to the level of blood pressure

List the goals of treatment for this patient. This is different from question 2

5pts

The ultimate goal of antihypertensive therapy for Mr G is a reduction in cardiovascular events. The higher the absolute cardiovascular risk, the more likely it is that Mr G will benefit from a more aggressive blood pressure goal. However, although cardiovascular events generally decrease with more intensive lowering of blood pressure, the risk of adverse effects, cost, and patient inconvenience increase as more medication is added.

According to recommendations made by the 2017 ACC/AHA guidelines) , a goal blood pressure of <130 mmHg systolic and <80 mmHg diastolic using out-of-office measurements (or, if out-of-office blood pressure is not available, then an average of appropriately measured office readings) in most patients who qualify for antihypertensive pharmacologic therapy. Identifying patients for initiation of antihypertensive drug therapy is presented above.

Some believe that, among selected hypertensive patients who qualify for antihypertensive therapy but who are at low absolute cardiovascular risk, a less aggressive goal blood pressure of <135/<85 mmHg (using out-of-office measurement) or <140/<90 mmHg (using an average of appropriately measured office readings) is appropriate.

Once blood pressure goal is determined on Mr. G, it should be recorded in his medical record, explicitly explained to the him. After antihypertensive therapy is initiated, Mr G should be re-evaluated and therapy should be increased monthly until adequate blood pressure control is achieved. Once blood pressure control is achieved, patients should be reevaluated every three to six months to ensure maintenance of control.

What nonpharmacologic therapies are necessary for this patient to achieve and maintain adequate blood pressure reduction? 5pts

Nonpharmacologic therapy — Treatment of hypertension should involve nonpharmacologic therapy (also called lifestyle modification) alone or in concert with antihypertensive drug therapy . We suggest that at least one aspect of nonpharmacologic therapy should be addressed at every office visit.

Dietary salt restriction – In well-controlled randomized trials, the overall impact of moderate sodium reduction is a fall in blood pressure in hypertensive and normotensive individuals of 4.8/2.5 and 1.9/1.1 mmHg, respectively. The effects of sodium restriction on blood pressure, cardiovascular disease, and mortality as well as specific recommendations for sodium intake, are discussed in detail elsewhere.

Potassium supplementation, preferably by dietary modification, unless contraindicated by the presence of chronic kidney disease or use of drugs that reduce potassium excretion

Weight loss – Weight loss in overweight or obese individuals can lead to a significant fall in blood pressure independent of exercise. The decline in blood pressure induced by weight loss can also occur in the absence of dietary sodium restriction , but even modest sodium restriction may produce an additive antihypertensive effect. The weight loss-induced decline in blood pressure generally ranges from 0.5 to 2 mmHg for every 1 kg of weight lost, or about 1 mmHg for every 1 pound lost.

DASH diet – The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is high in vegetables, fruits, low-fat dairy products, whole grains, poultry, fish, and nuts and low in sweets, sugar-sweetened beverages, and red meats. The DASH dietary pattern is consequently rich in potassium, magnesium, calcium, protein, and fiber but low in saturated fat, total fat, and cholesterol. A trial in which all food was supplied to normotensive or mildly hypertensive adults found that the DASH dietary pattern reduced blood pressure by 6/4 mmHg compared with a typical American-style diet that contained the same amount of sodium and the same number of calories. Combining the DASH dietary pattern with modest sodium restriction produced an additive antihypertensive effect. These trials and a review of diet in the treatment of hypertension are discussed in detail elsewhere.

Exercise – Aerobic exercise, and possibly resistance training, can decrease systolic and diastolic pressure by, on average, 4 to 6 mmHg and 3 mmHg, respectively, independent of weight loss. Most studies demonstrating a reduction in blood pressure have employed three to four sessions per week of moderate-intensity aerobic exercise lasting approximately 40 minutes for a period of 12 weeks.

Limited alcohol intake – Women who consume two or more alcoholic beverages per day and men who have three or more drinks per day have a significantly increased incidence of hypertension compared with non drinkers . Adult men and women with hypertension should consume, respectively, no more than two and one alcoholic drinks daily

What reasonable pharmacotherapeutic options are available for controlling this patient’s blood pressure? 5pts

Pharmacologic therapy — In large-scale randomized trials, pharmacologic antihypertensive therapy, as compared with placebo, produces a nearly 50 percent relative risk reduction in the incidence of heart failure, a 30 to 40 percent relative risk reduction in stroke, and a 20 to 25 percent relative risk reduction in myocardial infarction These relative risk reductions correspond to the following absolute benefits: antihypertensive therapy for four to five years in patients whose blood pressure is 140 to 159 mmHg systolic or 90 to 99 mmHg diastolic prevents a coronary event in 0.7 percent of patients and a cerebrovascular event in 1.3 percent of patients for a total absolute benefit of approximately 2 percent

Equal if not greater relative risk reductions have been demonstrated with antihypertensive treatment of older hypertensive patients (over age 65 years), most of whom have isolated systolic hypertension. Because advanced age is associated with higher overall cardiovascular risk, even modest and relatively short-term reductions in blood pressure may provide absolute benefits that are greater than that observed in younger patients.

My preferred therapy for Mr G would a Long acting dipyridamole calcium channel blocker like amlodipine and then add an additional group of anti hypertensive if the treatment is not meeting the goal. This is contrary to the recommendations by JNC-8. The reason for my preferred treatment option is to monitorthe effect of one medication before adding an additional group. Also Mr G problem isnon compliant with very few comorbidity.

Amlodipine

Amlodipine (Novasc) Oral: Initial: 2.5 to 5 mg once daily; will titrate every 1 to 2 weeks as needed based on Mr G’s response; maximum: 10 mg/day (ACC/AHA [Whelton 2017])

Classification: Norvasc is an anti hypertensive , it belongs to Dihydropyridine

calcium channel blocker

Mechanism of action :Amlodipine is a calcium channel blocker that acts by inhibiting the influx of calcium ions into the myocytes and vascular smooth layer, thereby blocking contraction of the cardiac muscle cell and vascular smooth muscle layer . The effect is to normalize blood pressure.

The Major adverse effects and side effects of amlodipine includes: Peripheral

edema ,Pulmonary edema , palpitation, Fatigue, drowsiness`,abdominal pain muscle cramps and weakness

Amlodipine is contraindicated in people with known hypersensitivity to amlodipine or its formulation, some argue that it is also contra indicated during breast feeding

Safety alerts and precautions ; it is recommended that amlodipine be initiated at a low dose. Symptomatic hypotension can occur; acute hypotension upon initiation is unlikely due to the gradual onset of action. Blood pressure must be lowered at a rate appropriate for the patient’s clinical condition.

Determination of clinical efficacy 15pts

Efficacy is the capacity to produce an effect (eg, lower BP). Efficacy can be assessed accurately only in ideal conditions (ie, when patients are selected by proper criteria and strictly adhere to the dosing schedule). Thus, efficacy is measured under expert supervision in a group of patients most likely to have a response to a drug, such as in a controlled clinical trial.         

Obviously, a drug (or any medical treatment) should be used only when it will benefit a patient. Benefit takes into account both the drug’s ability to produce the desired result (efficacy) and the type and likelihood of adverse effects (safety). Cost is commonly also balanced with benefit ( ESH/ESC 2013 )

Amlodipine is an excellent first-line choice among the myriad options of antihypertensive agents. According to (Packer M, Carson P, Elkayam U et al ), amlodipine was highly effective for the treatment of HTN and stable angina as evidenced by the fewer hospitalizations for unstable angina and revascularization in randomized controlled trials Amlodipine has also shown robust reductions on CV end points (especially stroke) but has not altered the prognosis in HF. Its abilities to prevent activation of counter-regulatory mechanisms, to slow the progression of atherosclerosis, to confer antioxidant properties and to enhance NO production are all unique actions. The management of HTN is shifting more towards dual or even triple combination therapy and requires a patient profiling approach as the number of comorbid states increases. Amlodipine is a superior option in the HTN armamentarium, not only for controlling BP but also for safely improving patient outcomes.

Clinical guideline for Hypertensive treatment .

Guideline recommendations: The 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults recommends if monotherapy is warranted, in the absence of comorbidities (eg, cerebrovascular disease, chronic kidney disease, diabetes, heart failure, ischemic heart disease), that thiazide-like diuretics or dihydropyridine calcium channel blockers may be preferred options due to improved cardiovascular end points (eg, prevention of heart failure and stroke). ACE inhibitors and ARBs are also acceptable for monotherapy. Combination therapy may be required to achieve blood pressure goals and is initially preferred in patients at high risk (stage 2 hypertension or atherosclerotic cardiovascular disease [ASCVD] risk ≥10%) (ACC/AHA [Whelton 2017]).

Outline specific lifestyle modifications for this patient. 5pts

Life style modification will optimize management of hypertension . This measure will lower blood pressure and prevent complications from high blood pressure, it will also reduce the need for additional medication. Some of the important life style changes that Mr G needs are : weight loss. When people think about losing weight, they sometimes make it more complicated than it really is. To lose weight, Mr G should either eat less or move more. If he does both of those things, it’s even better. But there is no single weight-loss diet or activity that’s better than any other. When it comes to weight loss, the most effective plan is the one that he will stick with.

Reduction in alcohol intake to no more than 2 standard drinks a day and smoking cessation are also advised. Information on hotline for smoking cessation can be provided

Clinical Course

DG two month follow up appointment, he states that he has been walking 2 miles a day, and has been adherent to his medications as prescribed He states that he is having difficulty with healthy eating. His average blood pressure is 140/82.

What instructions should you give the patient at this point in his therapy. 5pts

At this point , Mr G has shown a n improvement in his blood pressure, He has made some progress in some of his life style, He is able to walk and is compliant with his medication but continues to have problem adhering to eating healthy. These positive changes have to be recognized while encouragement on healthy diet is needed. He may be referred to a Nutritionist to address the problem.

What changes in therapy would you recommend if the patient now complains of intolerable adverse effects due to the current antihypertensive drug therapy. Outline an appropriate change to his current therapy. Include rationale and clinical guideline used to support the change.

10pts

Thiazide diuretics is an option in managing Mr G if he can not tolerate a calcium channel blocker. The preferred thiazide diuretic in patients with primary hypertension is chlorgalidone since major trials such as ALLHAT have shown benefit with this regimen. There is little, if any, evidence that hydrochlorothiazide improves cardiovascular outcomes. Hydrochlorothiazide is both less potent and shorter acting than chlorthalidone and indapamide. (Roush GC, Ernst ME, Kostis JB, et al 2015)

According to Roush GC , et al (2015)One problem with low-dose chlorthalidone that there is no 12.5 mg tablet. Thus, 25 mg tablets of generic chlorthalidone need to be cut in half; however, these tablets are not scored, and attempts to halve them may result in uneven dosing. In addition, in patients who require combination therapy, fixed-dose combination pills of chlorthalidone with ACE inhibitors and long-acting calcium channel blockers are not available (in contrast to hydrochlorothiazide. Indapamide, an alternative to chlorthalidone, has both a low-dose option available (1.25 mg) and a fixed-dose combination with an ACE inhibitor .

What changes in therapy would you recommend if the patient is tolerating the current drug therapy but had not achieved the desire BP control (average BP162/88)? Outline an appropriate change to her current therapy. Include rationale and clinical guideline used to support the change.

10pts

When amlodipine failed to control Mr G’s blood pressure, another group of antihypertensive should be introduced, a term known by clinicians as combination therapy. Two major issues related to combination therapy include the use of combination therapy as first-line therapy and addition of a second drug when the goal blood pressure is not achieved with monotherapy.

Recommendations for combination therapy were made by the European Society of Hypertension/European Society of Cardiology (ESH/ESC), by the Joint National Committee 8 panel (JNC-8), and by the American and International Societies of Hypertension (ASH/ISH) ( Chow CK , 2017).

First-line combination therapy — Administering two drugs as initial therapy should be considered when the blood pressure is more than 20/10 mmHg above goal, as recommended by the ESH/ESC, the ASH/ISH, and by some members of the JNC-8 panel (Chow, CK,2017). This strategy may increase the likelihood that target blood pressures are achieved in a reasonable time period. Fixed-dose combination preparations are available that may improve patient compliance, blood pressure control, and, if both drugs are given at lower doses, reduce side effects

Based upon the results of the ACCOMPLISH trial , I will recommend the use of a long-acting dihydropyridine calcium channel blocker plus a long-acting angiotensin-converting enzyme (ACE) inhibitor/ARB (such as amlodipine plus benazepril plus as used in ACCOMPLISH)

References

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https://www.cdc.gov/nchs/data/ahcd/namcs_summary/2014_namcs_web_tables.pdf.

Siu AL, U.S. Preventive Services Task Force. Screening for high blood pressure in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2015; 163:778.

Reboussin DM, Allen NB, Griswold ME, et al. Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 2018; 71:e116.

American College of Obstetricians and Gynecologists (ACOG), Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122-1131. doi: 10.1097/01.AOG.0000437382.03963.88. [PubMed 24150027]

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Go AS, Bauman M, King SM, et al. An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention [published online November 15, 2013]. Hypertension. [PubMed 24243703]

Packer M, Carson P, Elkayam U et al. Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (prospective randomized amlodipine survival evaluation 2). JACC Heart Fail 2013;1:308–14. doi:10.1016/j.jchf.2013.04.004 [PubMed]

ESH/ESC Task Force for the Management of Arterial Hypertension. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens 2013; 31:1925.

Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31:1281.

Roush GC, Ernst ME, Kostis JB, et al. Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects. Hypertension 2015; 65:1041.

Chow CK, Thakkar J, Bennett A, et al. Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review. Lancet 2017; 389:1035.